MediciNova completes last patient visit in double-blind Phase 2b/3 COMBAT-ALS trial of MN166

AI Market Summary
MediciNova reported last patient's last visit completion for the double-blind phase of its Phase 2b/3 COMBAT-ALS trial of MN166 (ibudilast), marking the end of blinded data collection ahead of planned topline results by end-2026. While this is a positive operational milestone, efficacy outcomes remain unknown, limiting immediate read-through to broader markets. Any near-term impact is likely confined to single-name biotech risk sentiment.
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MediciNova said it has completed the last patient’s final visit in the double-blind portion of COMBAT-ALS, its Phase 2b/3 trial of MN-166 (ibudilast) for amyotrophic lateral sclerosis. The study randomized 234 participants, and data collection for the double-blind phase has now finished, though efficacy results have not been released. The company’s shares are listed on Nasdaq and the Tokyo Stock Exchange.