Novartis said its experimental cardiovascular drug pelacarsen failed in a large clinical trial. The treatment had been widely viewed as a potential breakthrough for preventing heart attacks, strokes and cardiovascular deaths. The setback surprised cardiologists who had been expecting Lp(a)-targeting drugs to play a major role in prevention.

Disney reported better-than-expected theme park performance, with attendance at its Florida and California parks up 3%, driven by domestic tourists and annual pass holders. Comcast’s Universal parks posted a 5% quarterly drop in overall profit, even as its newly opened large-scale park is expected to support demand. The divergence highlights uneven conditions in the broader Orlando market.

Microsoft reported fiscal 2026 fourth-quarter results with revenue of $90 billion, up 17.8% year over year, and net profit of $35.8 billion, up 31.6%, both ahead of market expectations. Capital expenditures for the quarter totaled $41 billion, a 69.4% increase from a year earlier, largely tied to building AI data centers. The stock rose more than 1% in after-hours trading after the report.

The Trump administration is moving to convert underused federal land—including the former nuclear enrichment site in Piketon, Ohio, and the Savannah River nuclear complex in South Carolina—into hyperscale AI data center campuses. The plan totals 11 gigawatts, with 2 gigawatts explicitly slated to be backed by natural-gas generation and paired with 2.6 gigawatts of battery storage. The initiative is being led by the U.S. Department of Energy and is partly funded by Japan. The move has raised expectations for longer-term U.S. natural-gas demand as a baseload power source for data centers.

Tesla reported second-quarter net profit of $1.1 billion, down 9% from a year earlier and below analysts’ $1.3 billion estimate. Revenue rose 25% to $28.2 billion. The company said profit per vehicle fell as it sharply increased spending on robotaxis, battery plants and Semi trucks. European gains offset weaker U.S. sales, while General Motors also posted a 30% profit drop, underscoring broader pressure on industry margins.

Canadian Prime Minister Mark Carney announced a package of West Coast infrastructure projects centered on expanding oil and gas export capacity to Asian markets. The plan includes a new pipeline from Alberta to British Columbia’s southern coast near Vancouver, multiple LNG terminals on B.C.’s northern coast to triple Canada’s LNG production, and expansions at the ports of Prince Rupert and Vancouver. Carney said the initiatives aim to reduce reliance on the United States and would “unlock” C$150 billion ($105 billion) in new investments.

Major egg producers including Cal-Maine Foods (CALM), Hickman’s Egg Ranch (HICK) and Versova agreed to pay $3.3 million to settle allegations they manipulated prices from 2022 to 2024, and to donate more than 53 million eggs. The settlement does not include an admission of wrongdoing. It requires the companies to cooperate with federal monitoring and adopt compliance programs to prevent price manipulation, according to court documents.

Extreme heat in the eastern United States is pushing the PJM grid, which spans from Chicago to Virginia Beach, toward what it expects to be its highest electricity demand in 20 years on Thursday. Energy Secretary Chris Wright has told grid operators to require data centers to run on backup power if needed to relieve pressure on the system. The region’s backup generators largely run on natural gas and diesel, lifting near-term demand for gas-fired generation and highlighting PJM’s limited buildout of energy-storage batteries.

The U.S. Nuclear Regulatory Commission has proposed a sweeping rewrite of radiation safety rules, arguing current requirements are too costly and exceed what is needed to protect health. The agency would keep existing annual dose limits for workers and the public, but eliminate the decades-old “as low as reasonably achievable” (ALARA) principle. It also proposed changes to simplify siting and licensing for new nuclear reactors, a shift that could reduce costs and speed approvals to support U.S. nuclear expansion.